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	Provedor de dados BJPS (1) Autor Sara,Udai Vir Singh (1) Som,Iti (1) Yasir,Mohd (1) Palavra-chave Brain targeting. (1) Haloperidol/in vitro study (1) Haloperidol/in vivo study (1) Haloperidol/pharmacokinetic (1) Haloperidol/quantification (1) High performance liquid chromatography/solid lipid nanoparticles (1) Plasma (1) Validation (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2017 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Development of a new HPLC method for in vitro and in vivo studies of haloperidol in solid lipid nanoparticles BJPS Yasir,Mohd; Sara,Udai Vir Singh; Som,Iti. ABSTRACT A simple and sensitive HPLC method was developed and validated for the quantification of haloperidol in solid lipid nanoparticles (SLNs). The developed method was used for detection of shelf life of haloperidol in SLNs. Calibration curve of haloperidol was also constructed in rat plasma using loratidine as internal standard. In vivo studies were performed on rats and concentration of haloperidol in brain and blood was measured for the determination of various pharmacokinetic and hence brain targeting parameters. Chromatogram separation was achieved using C18 column as stationary phase. The mobile phase consisted of 100 mM/L potassium dihydrogen phosphate-acetonitrile-TEA (10:90:0.1, v/v/v) and the pH was adjusted with o-phosphoric acid to 3.5.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Haloperidol/quantification; Haloperidol/pharmacokinetic; Haloperidol/in vitro study; Haloperidol/in vivo study; High performance liquid chromatography/solid lipid nanoparticles; Plasma; Validation; Brain targeting.. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200623 Registros recuperados: 1 Primeira ... 1 ... Última

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